Endocrine Abstracts

Graves’ (GD) hyperthyroidism induces accelerated bone turnover that leads to diminished bone mineral density (BMD). Recent studies indicate the associations between VDR gene and autoimmune diseases. The role of VDR allelic variants in predisposition to primary osteoporosis is also recognized. The authors analyzed if VDR polymorphisms: BsmI, ApaI, TaqI and FokI may predispose women with Graves’ hyperthyroidism to BMD reduction. The subjects were 7...

Introduction: The etiology of this autoimmune disorder results from the presence of stimulating antibodies binding to TSH receptor. The disease has a strong genetic background associated with HLA and CTLA-4 genes.The aim of study: The aim of this study was to estimate the influence of polymorphic variants of ESR1 gene on the bone mineral density in young premenopausal women with Grave’s disease (GD).Material and methods...